EFFECTIVENESS OF TOMATO (SOLANUM LYCOPERSICUM) NANOHERBAL AS ANTIHYPERGLYCEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RAT

Diabetes merupakan penyakit kronis yang terjadi di saat insulin diproduksi oleh tubuh tidak bisa digunakan secara efektif maupun organ pankreas mengalami masalah dimana dapat sebagaimana mestinya. Kebaruan penelitian ini karena meneliti tentang efektivitas nanoherbal tomat (solanum lycopersicum) sebagai antihiperglikemia pada tikus diabetes terinduksi streptozotocin. Penelitian bertujuan untuk sistematis menganalisis dan meninjau hewan putih diinduksi STZ. Metode pencarian elektronik dilakukan dengan mencari MEDLINE melalui platform PubMed, Web of Science, Embase Ovid, CINAHL, Scopus. Penulis juga akan literatur kelabu seperti makalah konferensi, laporan teknis, tesis, disertasi Google Scholar, Google, OpenGrey, ProQuest Disertasi Tesis, British Library Ethos. setiap database hingga November 2021 menggunakan kata kunci MeSH. Istilah dibagi menjadi tiga komponen, yaitu komponen populasi meliputi kata-kata “hewan”, “model hewan”, “studi praklinis”, “hewan percobaan”, laboratorium, ” "tikus", "kelinci", "tikus diabetes", "model hewan". Komponen intervensi “Solanum Lycopersicum” “tomat,” “nano herbal,” Akhirnya, istilah "diabetes mellitus, tipe 2," mellitus tergantung insulin," "NIDDM," "gangguan metabolisme glukosa," "penyakit metabolik," "hiperlipidemia," "hiperglikemia," "insulin resistensi," "intoleransi glukosa." Hasilnya menunjukkan bahwa Efektifitas Nanoherbal (Solanum Lycopersicum) Antihiperglikemia Streptozotocin. Kesimpulan penelitiannya ada bukti praklinis Solanum Lycopersicum dalam menurunkan gula darah tinggi.Kata kunci: Diabetes; Streptozotocin; Tomat.AbstractDiabetes is a chronic disease that occurs when the produced by body cannot be used effectively or pancreas has problems where properly. The novelty this study it examines effectiveness tomato as an antihyperglycemic agent in streptozotocin-induced diabetic rats. This review aims to systematically analyze and animals studies STZ-induced white mice. An electronic search was carried out searching for through PubMed platform, Scopus platforms. Authors will also gray literature such conference papers, technical reports, theses, dissertations on Open Grey, Dissertations Theses, author searched each until using keyword term divided into three components, namely population component which includes words “animal”, “animal model”, “preclinical study”, “experimental animal”, “laboratory animal,” “rat”, “rabbit ", "diabetic mice", "animal models". intervention with “tomato,” Finally, would “diabetes type 2,” “non-insulin dependent mellitus,” “NIDDM,” “metabolic disorder. glucose," "metabolic disease," "hyperlipidemia," "hyperglycemia," resistance," "glucose intolerance." results showed Tomato Antihyperglycemia Streptozotocin-induced rat. conclusion there preclinical evidence effective lowering high blood sugar.